Refractory Fungal Keratitis Caused by Acrophialophora fusispora: A Case Report and Literature Review

Acrophialophora fusispora is a filamentous fungus that found in soil and rarely infects humans. We herein report the first case of fungal keratitis caused by A. Japan present review literature on human infections with species. A 62-year-old Japanese male immunosuppressive therapy developed after removal corneal foreign body from his left eye. Voriconazole eye drops systemic for post-traumatic did not resolve infection, patient required therapeutic transplant. The isolate was identified as based nucleotide sequence internal transcribed spacer region. In drug susceptibility test, minimum inhibitory concentration voriconazole 0.5 μg/mL. Based this previous cases review, often refractory.